RESEARCH


HOW DOES SHORT-TERM PLASTICITY AFFECT SENSORY AND COGNITIVE PROCESSING?
Our primary goal in discovering the mechanisms of short-term plasticity is to be able to manipulate synapses in vivo and determine how synaptic plasticity regulates the neural circuits that drive behavior. The discovery that synaptotagmin 7 mediates facilitation at most synapses in the mammalian brain allows to perform the first experiments designed to link short-term plasticity to behavior. We use a wide array of behavioral assays to evaluate cognitive and sensory processing in Syt7 knockout mice.